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Engineered cell-targeted LNPs and a broad ionizable lipid library.

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ENCLNP

Engineered Cell-Targeted LNP

EnC-LNP design: conventional LNP with target factors, versatile cargo, cell-specific access and cells of interest
EnC-LNP design — target factors conjugated to cLNP enable cell-specific access for RNA, DNA and other cargo formats.

MagicRNA Engineered Cell-targeted LNP (EnC-LNP) is based on target factors conjugated with conventional LNP (cLNP), enabling LNP cargos (mRNA, DNA, Other Nucleic Acid Molecules) to access specific cells of the immune system, the central nervous system, tumor cells, and any cell of your interest.

EnC-LNP maintains similar characteristics, stability and morphology to cLNP, achieves efficient target-cell delivery in NHP, and the precise design of the targeting factor supports an achievable CMC.

EnC-LNP has demonstrated good cell specificity and excellent delivery efficiency at various doses in experiments on non-human primates (NHP).

  • Cell-specific accessImmune cells, CNS, tumor cells and other cell types of interest.
  • Multiple cargo formatsmRNA, DNA and other nucleic acid formats.
  • NHP validatedEfficient delivery and specificity demonstrated in non-human primates.
  • CMC-ready designPrecise target-factor design supports scalable manufacturing.
Cryo-EM comparison of cLNP and EnC-LNP morphology
Similar morphology, engineered targeting. Cryo-EM comparison of conventional LNP and EnC-LNP. The engineered targeting approach preserves the particle structure and stability of cLNP.